Conferencia de Ramón Vilar


C O N F E R E N C I A S     M A G I S T R A L E S  

en el 

52° CONGRESO MEXICANO DE QUÍMICA, 

36° CONGRESO NACIONAL DE EDUCACIÓN QUÍMICA

 Y LA EXPO QUÍMICA 2017

  " La Química nos une"

a celebrarse del 26 al 29 de septiembre 2017, en Puerto Vallarta, Jalisco, México, teniendo como sede Hotel The Westin Resort & Spa Puerto Vallarta 

 
Prof. Ramon Vilar

Faculty of Natural Sciences, Department of Chemistry

Professor of Medicinal Inorganic Chemistry   

Imperial College London 

 

His research focuses on the following areas:

•Medicinal Inorganic Chemistry

•Chemical Biology

•Molecular recognition and self-assembly

•Molecular Imaging

 

Overview

Synthesis of metal-containing drugs and study of their interactions with

DNA (as potential anticancer drugs) and proteins (as inhibitors of phosphatases).

Development of metal-containing probes for biomedical imaging (MRI and optical)

Organometallic chemistry of palladium (cross-coupling reactions, development of fast chemical processes for PET labelling)

Development of receptors for selective recognition of anions (phosphate, chloride, arsenate) and cations (mercury, lead) for the development of chemical sensors

Anion templated synthesis of supramolecular assemblies

More Publications

*C.-Q. Zhou, T.-C. Liao, Z.-Q. Li, J. Gonzalez-Garcia, M. Reynolds,M. Zou, R. Vilar,

"Dinickel–Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes", Chem. Eur. J. 2017, 23, 4713 (DOI: 10.1002/chem.201700276).

B. Klejevskaja, A. L. B. Pyne,  M. Reynolds,  A. Shivalingam,  R. Thorogate,  B.W. Hoogenboom,  L. Ying, R. Vilar, "Studies of G-quadruplexes formed within self-assembled DNA mini-circles", Chem. Commun. 2016, 52, 12454-12457 (DOI:  10.1039/C6CC07110D) 

 *A. Shivalingam, M. A.  Izquierdo, A. Le Marois, A. Vyšniauskas, K. Suhling, M. K. Kuimova and R Vilar, "The interactions between a small molecule and G-quadruplexes are visualised by fluorescence lifetime imaging microscopy", Nature Comm. 2015, 6, 8178 (doi:10.1038/ncomms9178)

 

For more details, visit the group's website:

http://www3.imperial.ac.uk/medinchem

 http://www.imperial.ac.uk/vilar-research-group

 

 

 Conference abstract 

"Targeting DNA with small molecules for imaging and therapeutic applications"

DNA can assemble in a wide range of different topologies such as Z-DNA, triplexes and quadruplexes. With the mounting evidence that several of these non-canonical DNA structures play key biological roles, there is increasing interest in developing small molecules that can interact selectively with a given topology. In particular, over the past few years there has been increasing interest in the development of selective binders for guanine-quadruplexes (G-quadruplexes). G-quadruplex DNA has been shown to play important roles in regulation of gene expression, telomere maintenance and replication and therefore have been proposed to be attractive anticancer drug targets. This lecture will focus on the use of molecular tools to help us understand the biological roles of G-quadruplexes as well as their potential as drug targets.  

Keywords: DNA, Quadruplexes, Bioinorganic, Imaging, Cancer 

 

 

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